The core biopsy--a minimally invasive procedure--is a common first-line approach to diagnose a breast mass, calcifications or enhancement MRI. Occasional patients present with a palpable mass that is easily accessed with a Tru-cut type core biopsy apparatus. Core Biopsy Diagnosis--The Bottom Line: Core biopsies diagnosed as cancer, suspected cancer, atypical ductal hyperplasia, papilloma or other complex papillary lesion, or fibroepithelial neoplasm; cannot exclude phyllodes tumor mandate excisional biopsy or curative treatment, where the diagnosis is unambiguous.
This article describes the historical classifications of breast density. Pioneers in classification of density include Leborgne in and Wolfe inwho described an increased risk of breast cancer in radiographically dense breast. The first qualitative classification of mammographic density patterns was described by Wolfe in
Fibrosis refers to a thickening or increase in the density of breast tissue. Fibrous breast tissues include ligaments, supportive tissues stromaand scar tissues. Sometimes these fibrous tissues become more prominent that the fatty tissues in an area of the breast, possibly resulting in a firm or rubbery bump.
If a clinical breast exam identifies a breast lump, calcifications that look suspicious are seen on a mammogram, or an ultrasound or MRI identifies an area that looks abnormal, typically the next step is a biopsy. A biopsy is a sample of cells or tissue. The biopsy is sent to a cytologist or pathologist who will look at it closely under a microscope and may also perform tests on the cells to learn more about them.
At first glance, adipose tissue seems to be a rather monotonous tissue, comprised mostly of adipocytes, fat-storing cells. These globular cells contain a single large lipid vacuole made up of triglycerides. Their main function is to maintain an energy balance by storing excess fat and releasing it when needed in the form of fatty acids.
Fibroadenomas are common benign breast tumours that display a characteristic pathological morphology, although several epithelial and stromal variations exist. A very rare histological finding is the presence of multinucleated giant cells throughout the stroma of a benign fibroadenoma. Cells of this type, which are more commonly found incidentally within the interlobular stroma of breast tissue, are benign and should not be mistaken for malignant cells on microscopic examination.
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