Stage 3 cancer means the breast cancer has extended to beyond the immediate region of the tumor and may have invaded nearby lymph nodes and muscles, but has not spread to distant organs. Although this stage is considered to be advanced, there are a growing number of effective treatment options. The difference is determined by the size of the tumor and whether cancer has spread to the lymph nodes and surrounding tissue.
Staging and grading usually happens after your breast tumour has been removed by surgery, as a pathologist will need to test the tissue in a laboratory and examine it under a microscope. The grade of a tumour indicates what the cells look like and gives an idea of how quickly the cancer may grow and spread. Tumours are graded between 1 and 3.
Despite the good responses of patients pts with stage III breast cancer to neoadjuvant chemotherapy NACmost eventually relapse and have a poor prognosis. Subsequent to the completion of NAC and surgery, we assessed the clinicopathological results and performed prognostic analyses. Statistical analyses concerning disease-free survival DFS or overall survival OS were conducted by a Cox proportional hazard model.
Stage 3 breast cancer is more advanced than stage 2 but is not considered metastatic. With stage 3, cancer has not spread from the breast to organs or other distant sites in the body. Instead, cancer cells are constrained to nearby axillary underarm lymph nodes or those beneath your sternum breastbone or clavicle collarbone.
What grade is the breast cancer? What size is the breast cancer? Cancer cells are given a grade according to how different they are to normal breast cells and how quickly they are growing.
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Study record managers: refer to the Data Element Definitions if submitting registration or results information. Colony-stimulating factors such as filgrastim may increase the number of immune cells found in bone marrow or peripheral blood and may help a person's immune system recover from the side effects of chemotherapy. Radiation therapy uses high-energy x-rays to damage tumor cells.
Hearing you have stage 3 breast cancer can bring many questions — about your diagnosis, survival, treatments, and more. First, stage 3 breast cancer means your cancer has spread beyond the tumor and has possibly gone to lymph nodes and muscle, but has not spread to nearby organs. Doctors divide stage 3 into more specific categories 3A, 3B, and 3C and the cancer subtype, meaning which type of breast cancer you have.